Induced pluripotent stem (iPS) cells have been generated fromhuman somatic cells by ectopic expression of four Yamanaka factors.\nHere, we report that Survivin, an apoptosis inhibitor, can enhance iPS cells generation from human neural progenitor cells (NPCs)\ntogether with one factor OCT4 (1F-OCT4-Survivin). Compared with 1F-OCT4, Survivin accelerates the process of reprogramming\nfrom human NPCs. The neurocyte-originated induced pluripotent stem (NiPS) cells generated from 1F-OCT4-Survivin resemble\nhuman embryonic stem (hES) cells inmorphology, surface markers, global gene expression profiling, and epigenetic status. Survivin\nkeeps high expression in both iPS and ES cells. During the process of NiPS cell to neural cell differentiation, the expression of\nSurvivin is rapidly decreased in protein level. The mechanism of Survivin promotion of reprogramming efficiency from NPCs\nmay be associated with stabilization of
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